« ...Acne affects more than 85 percent of teenagers but frequently continues into adulthood. Although there are more than 2 million visits to office-based physicians per year for patients in the age range of 15 to 19 years, the mean age at presentation for treatment is 24 years, with 10 percent of visits taking place when patients are between the ages of 35 and 44 years. Patients evaluated at tertiary care centers are prone to depression, social withdrawal, anxiety, and anger and are more likely to be unemployed than persons without acne. Scarring can lead to lifelong problems in regard to self esteem. The direct cost of acne in the United States is estimated to exceed $1 billion per year, with $100 million spent on over-the-counter acne products....
...Inflammation Is the Result of a Multi-faceted ProcessHormonal changes are at the root of acne pathogenesis.The primary target of acne is the pilosebaceous unit of the follicle.Hormones stimulate increased production of lipids in the follicle.Inflammation probably arises from the presence of prostaglandins and cytokines that are attracted to the lipids within the follicle.Some individuals may be genetically prone to overactive inflammatory pathways, which increases their chances of having severe inflammatory acne....»
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